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Step 3: Optimization phase (weeks 3-8) Based on assessment results, establish your working protocol: Dose: Your minimum effective dose (typically 75-200mcg) Frequency: 3-5 times weekly based on tolerance observations Timing: Your optimal pre-bedtime window Track results weekly and make minor adjustments as needed

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Following menopause estrone (E) plays an important role, with high levels reportedly synthesised in adipose tissue from the adrenally derived precursor DHEA [54, 55]